Teneligliptin and metformin are FDA-approved medications recently introduced for managing type 2 diabetes. This study aims to develop UV spectrophotometric methods for the simultaneous quantification of teneligliptin and metformin in pharmaceutical formulations, alongside conducting forced degradation studies under four distinct stress conditions. The methods utilize Vierordt's Method with distilled water as the solvent. The absorption maxima for metformin and teneligliptin were identified at 230.4 nm and 245 nm, respectively, with no interference between the two. Stability assessments were carried out under acidic, alkaline, oxidative (peroxide) and thermal stress. The forced degradation studies highlighted the robustness of the developed method under various stress conditions. The method adhered to Beer’s law within the concentration ranges of 2-14 μg/ml for metformin and 10-40 μg/ml for teneligliptin. Statistical validation confirmed the method’s reliability. This approach proved to be rapid, precise and cost-effective for routine analysis of pharmaceutical formulations. Insights from the degradation studies may guide the formulation of more stable products and inform the proper storage practice.
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